In the field of nanoparticle and macromolecule characterization in dispersion, measurement precision is critical. Whether you’re ensuring the quality of a biopharmaceutical product or monitoring the colloidal stability of a formulation, users of Dynamic Light Scattering (DLS) face a well-known challenge: the technique’s extreme sensitivity to large particles, even in very low concentrations.

To address this issue, Malvern Panalytical has introduced a major breakthrough in its Zetasizer Advance range: the patented Adaptive Correlation technology.

What is Adaptive Correlation?

Adaptive Correlation is an innovative method for acquiring and processing DLS data. Unlike conventional approaches, this technology doesn’t discard data deemed noisy or erroneous. It analyzes and statistically classifies it into two categories: transient and steady state.

• Steady-state data represents particles that are consistently present in the detection volume.
• Transient data, often due to aggregates or contaminants, is identified but not discarded, it is analyzed separately.

This unique approach not only improves the accuracy of measurements for the main particle population, but also provides valuable insight into the presence of rare aggregates or contaminants without compromising measurement robustness.

Why Choose Adaptive Correlation?

• Faster measurements: The adaptive detection process allows for up to 3x faster measurements without sacrificing precision.
• Less sample prep required: The system is more tolerant to dust and aggregates, reducing the need for expensive filtration (e.g., 20 nm filters).
• Improved reproducibility: More stable results, even on sensitive samples like proteins or polydisperse suspensions.
• Early aggregate detection: By analyzing transient events separately, Adaptive Correlation can identify rare aggregate populations before they distort overall results.
• No data discarded: All sub-measurements are retained and analyzed, ensuring full transparency and higher confidence in results.

In Conclusion

Adaptive Correlation is transforming how DLS measurements are performed making them more reliable, faster, and better suited for complex systems. Integrated into the Zetasizer Advance range, this technology helps you obtain more accurate data, with less effort and, most importantly, with greater confidence. Read more about the scientific foundation of Adaptive Correlation in the full Nature Scientific Reports article or contact us to know more.