Malvern Panalytical MicroCal PEAQ-DSC Automated

Gold standard protein stability analysis for the regulated environment

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The MicroCal PEAQ-DSC Automated system delivers high throughput, highly sensitive protein stability analysis with low sample consumption, in an automated, integrated platform for increased productivity.  All cell filling and cleaning functions are fully automated for walk-away operation. Data generated by the MicroCal PEAQ-DSC Automated provide critical guidance for biopharmaceutical development in protein engineering, (pre)formulation development, process development, manufacturing change control and biosimilarity and biocomparability studies. Unattended operation enables 24-hour screening, while the integrated software streamlines workflows, facilitates non-subjective data analysis, performance qualification and compliance with 21 CFR Part 11 and Annex 11 regulations, all delivering high integrity data and driving productivity in biopharmaceutical research. 

Measuring Types

Temperature midpoint (TM)
Enthalpy (ΔH)
Heat capacity change (ΔCp)

Detection

Differential Scanning Calorimetry (DSC)

Specifications

Sample volume: 325 µL
Sample Capacity: 288 (6 x 96-well plates)
Typical sample concentration: 0.0.1 mg/mL – 10 mg/mL
Sample storage temperature: 4°C – 40°C
System noise: 0.05 uCal/°C2
Baseline repeatability: 1 μCal/°C 2
Response time: 5s 2
Repeatability: <0.2 µCal/°C 3
Reproducibility: <0.08°C St. Dev. TM and <2% RSD on ΔH 4
System reproducibility: <0.1°C St. Dev. TM and <5% RSD on ΔH 4
Multiple feedback modes: Yes (passive, high gain and low gain)
Temperature range: 2°C to 130°C
Maximum scan rate: 240°C/h
Reverse scanning: Yes
Pressure perturbation calorimetry (PPC): N/A
Cleaning routines: 3 pre-programmed routines
Cleaning solvents: Water and detergent used as standard

Sample Throughput

Approx. 50 samples / day

Operating Environment

Operating temperature: +10°C to +28°C
Storage temperature: -20°C to +50°C
Humidity: 10% to 70%, non-condensing (10% to 90% for storage)
Ingress Protection (IP) rating: IP21
Power: 100-240 V A/C, 50/60 Hz, 70 W (cell), 400 W (max, autosampler), PC as supplied
Certification: CE (EN61010-1), EMC (EN61326-2-1, EN61326-1, FCC, ICES, VCCI), ISO9001:2008

Software

21 CFR part 11, with PEAQ-Compliance software option
Network ready: Yes with email alert capability

Dimensions

Dimensions 1010 x 680 x 700 mm (W, D, H) (calorimeter + wash station)
Weight: 25 kg

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