Malvern Panalytical MicroCal PEAQ-DSC

Gold standard protein stability analysis for research applications

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The MicroCal PEAQ-DSC system provides highly sensitive, easy-to-use microcalorimetry that helps reduce the time and cost associated with stability testing and comparability analysis.  The MicroCal PEAQ-DSC is a manual instrument with a cleaning device, which can be upgraded to an automated version upon request. Data generated by the MicroCal PEAQ-DSC provides critical guidance for biopharmaceutical development in protein engineering, (pre)formulation development, process development, manufacturing change control and biosimilarity and biocomparability studies. The integrated software streamlines workflows, facilitates non-subjective data analysis, performance qualification and compliance with 21 CFR Part 11 and Annex 11 regulations, all delivering high integrity data and driving productivity in biopharmaceutical research. 

Measuring Types

Temperature midpoint (TM)
Enthalpy (ΔH)
Heat capacity change (ΔCp)

Detection

Differential Scanning Calorimetry (DSC)

Cell

Cell: Capillary
Cell material: Tantalum
Cell volume: 130 ul

Specifications

Sample volume: 250 µL (manual filling)
Typical sample concentration: 0.0.1 mg/mL – 10 mg/mL
System noise: 0.05 uCal/°C2
Baseline repeatability: 1 μCal/°C 2
Response time: 5s 2
Repeatability: <0.2 µCal/°C 3
Reproducibility: <0.08°C St. Dev. TM and <2% RSD on ΔH 4
System reproducibility: <0.1°C St. Dev. TM and <5% RSD on ΔH 4
Multiple feedback modes: Yes (passive, high gain and low gain)
Temperature range: 2°C to 130°C
Maximum scan rate: 240°C/h
Reverse scanning: Yes
Pressure perturbation calorimetry (PPC): N/A, manual cleaning device with guided workflows
Cleaning solvents: Water and detergent (Contrad 90) used as standard

Sample Throughput

Approx. 6 samples analyzed / 8 h

Operating Environment

Operating temperature: +10°C to +28°C
Storage temperature: -20°C to +50°C
Humidity: 10% to 70%, non-condensing (10% to 90% for storage)
Ingress Protection (IP) rating: IP21
Power: 100-240 V A/C, 50/60 Hz, 70 W (cell), 400 W (max, autosampler), PC as supplied
Certification: CE (EN61010-1), EMC (EN61326-2-1, EN61326-1, FCC, ICES, VCCI), ISO9001:2008

Software

21 CFR part 11, with PEAQ-Compliance software option
Network ready: Yes with email alert capability

Dimensions

Dimensions 200 x 440 x 190 mm (W, D, H) (calorimeter + wash station)
Weight: 8.2 kg

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