Malvern Panalytical MicroCal PEAQ-iTC

Label-free in solution measurement of binding affinity and thermodynamics

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MicroCal ITC isothermal titration calorimeters allow direct, label-free in solution measurement of binding affinity and thermodynamics in a single experiment, enabling the accurate determination of binding constants (KD), reaction stoichiometry (n), enthalpy (ΔH) and entropy (ΔS). This provides a complete thermodynamic profile of the molecular interaction. ITC goes beyond binding affinities and can elucidate the mechanisms underlying molecular interactions.  

Measuring Types

Affinity (KD)
Enthalpy ∆H
Entropy ∆S
Stoichiometry (n)


Isothermal titration microcalorimetry


Sample volume: 280 µL
Cell volume: 200 µL
Injection syringe volume: 40 µL
Injection volume precision: < 1% @ 2 µL
Cell material: hastelloy
Baseline noise: 0.15 ncal/s
Temperature range: 2°C to 80°C
Temperature stability: ± 0.00012°C

Sample Throughput

8-12 samples per 8 h day
Up to 42 samples per 24 h (SIM) (after upgrade to automated version)


Intuitive software with streamlined user interface that guides the user to final figures and presentation quality graphs quickly and easily.
Experiment design simulation, batch evaluation of large data sets, automated assessment of data quality
Open multiple experiments in a single session
Supports many automated fitting models


Dimensions 430 x 380 x 460 mm (W, D, H) (calorimeter + wash station)
Weight: 13.6 kg